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Trahan Ranch / Patrick Tighe Architecture

first_img United States CopyHouses•United States Year:  “COPY” ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/538252/trahan-ranch-patrick-tighe-architecture Clipboard 2008 Save this picture!© Art Gray Photography+ 13 Share Architects: Patrick Tighe Architecture Area Area of this architecture project Trahan Ranch / Patrick Tighe ArchitectureSave this projectSaveTrahan Ranch / Patrick Tighe Architecture Houses “COPY” Area:  3200 ft² Area:  3200 ft² Year Completion year of this architecture project Year:  2008 Photographs Projects ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/538252/trahan-ranch-patrick-tighe-architecture Clipboard photographs:  Art Gray PhotographyPhotographs:  Art Gray PhotographySave this picture!© Art Gray PhotographyText description provided by the architects. The project is a residential compound situated in the heart of Texas hill country. The 3,200 square foot residence is on a fourteen acre sloped site with native oaks, natural springs and unobstructed views. The layout of the house is a direct response to the site conditions.Save this picture!Floor PlanThe plan is organized to integrate and enhance the many features of the landscape. A panoramic view that spans 260 degrees is experienced as well as other more site specific orientations. The front of the house is made of heavy materials that rise from the earth.Save this picture!© Art Gray PhotographyThe heavy, solid, grounded front is in sharp contrast to the more ephemeral back. At the down slope side of the house, the structure becomes lighter and opens to the landscape. Steel pipe columns splay at unsuspecting angles dancing along the rugged landscape.Save this picture!© Art Gray PhotographyProject gallerySee allShow lessBOX 298 Building / Andrade Morettin Arquitetos AssociadosSelected ProjectsCurucura House / Unoencinco ArquitectosSelected Projects Share ArchDaily Trahan Ranch / Patrick Tighe Architecture CopyAbout this officePatrick Tighe ArchitectureOfficeFollowProductsWoodGlassSteel#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousesHousesUnited StatesPublished on August 20, 2014Cite: “Trahan Ranch / Patrick Tighe Architecture” 20 Aug 2014. ArchDaily. Accessed 11 Jun 2021. ISSN 0719-8884Browse the CatalogPanels / Prefabricated AssembliesTechnowoodSiding Façade SystemPlasticsMitrexSolar SidingMetal PanelsAurubisCopper Alloy: Nordic BronzeArmchairsAndreu WorldGrand Raglan – Lounge ChairSinksBradley Corporation USASinks – Frequency® FL-SeriesPlantingSikaGreen RoofsStonesCosentinoSilestone Surfaces – Ethereal CollectionMetal PanelsLongboard®Aluminum Battens – Link & Lock – 8″Panels / Prefabricated AssembliesFranken-SchotterFacade Panels – Dietfurt LimestoneWindowsRabel Aluminium SystemsMinimal Casement Windows – Rabel 8400 Slim Super Thermal PlusWoodGustafsWood Cladding in St. Erik Eye HospitalLightsKKDCLighting – Groove FLEXMore products »Save世界上最受欢迎的建筑网站现已推出你的母语版本!想浏览ArchDaily中国吗?是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my streamlast_img read more

 

FULTON – A5 A1 / Agence Bernard Bühler

first_img Area:  6000 m² Year Completion year of this architecture project Letsgrow, Freddy Charrier Bouygues Construction, Habitat Social France General Contractor: Technical Engineering Office:SEROEnvironment Engineering Office:TRIBUAssociation:N°5 Marie Bühler ArchitecteClients:ICF La SablièreArchitect In Charge:Bernard Bühler, Marie BühlerCity:Paris-13E-ArrondissementCountry:FranceMore SpecsLess SpecsSave this picture!© Sergio GraziaSave this picture!© Sergio GraziaText description provided by the architects. ICF La Sablière owns the Fulton block, located in the 13th arrondissement of Paris, on the banks of the Seine. The existing real estate complex known as “Fulton” was built in the 1950s by architect Daniel Michelin and is occupied by 133 dwellings. The site benefits from a very beautiful location, clear, in front of the seine, near the bridge of Bercy in the East and the museum of fashion and design at the West, a contemporary building realized by the architects Jakob + Macfarlane.Save this picture!© Sergio GraziaThe building is located on the Quai d’Austerlitz and marks the corner of Fulton and Bellièvre streets. The operation comprises 87 social housing units, 2 shops on the ground floor, 30 parking spaces in the basement and a garden in the heart of the lot.The garden marks between the two towers a breach enter the East / West, based on the urban study, and is extended by a set of terraces until the RDC. Save this picture!DiagramThe operation is consists of a base superimposed by two towers of 11 floors separated by an urban breach. This plinth consolidating the project an a way alive along the Quai d’Austerlitz thanks to the presence of a projecting large commercial showcase. This screen offers a good visibility to the activities that it welcomes. This block to be extricating itself from the concrete base. It thus creates two accesses to the shops in continuity of a wide pedestrian area.Save this picture!© Sergio GraziaThe operation is part of a logic of strong urban structuring. The two towers of flats mark the corners of Fulton / Bellièvre streets with the Quai d’Austerlitz. On the other hand, these two emergences are separated by a void that seems to be dug between the buildings. The breach created offers a perspective from the heart of the parcel to the Seine and, conversely, from the Quai d’Austerlitz, it gives to read the third floor landscape and vegetated depth of the Fulton block. Save this picture!Ground Floor PlanFrom the outside, the dwellings are defined by generous balconies oriented towards the Seine that wind in the fault around the 2 buildings. Thus, each accommodation offers a view of the Seine but also on the garden in “heart of ilot”. The double or triple-oriented units provide luminous quality and a significant amount of solar energy for the comfort of use.Save this picture!© Sergio GraziaThe railing of the balconies are in dichroic glass. That is to say that depending on the orientation, the angle of view, a color will appear appearing from blue to yellow, going through the green. The particularity of this glazing also allows to protect the interior of the balconies. Thus, the tenant may be on his balcony without being seen, protected by the color of the glazing.Project gallerySee allShow lessAdjaye, BIG, Sou Fujimoto and 4 Other Teams Reveal Proposals for Edinburgh’s Ross Pa…Architecture NewsQUIKRETE One Bag Wonder 2.0 Project ContestBuilt Projects & MasterplansProject locationAddress:3 Rue Fulton, 75013 Paris-13E-Arrondissement, FranceLocation to be used only as a reference. It could indicate city/country but not exact address. Share Architects: Agence Bernard Bühler Area Area of this architecture project ArchDaily Photographs CopyHousing•Paris-13E-Arrondissement, France Year:  FULTON – A5 A1 / Agence Bernard Bühler Photographs:  Sergio Grazia, Agence Bernard Bühler, Milene Servelle Manufacturers Brands with products used in this architecture project Projects Housing Manufacturers: AGC, FEHR, Reckli, SCHOTT, Saint-Gobain 2017 ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/873894/fulton-nil-a5-a1-agence-bernard-buhler Clipboard FULTON – A5 A1 / Agence Bernard BühlerSave this projectSaveFULTON – A5 A1 / Agence Bernard Bühler ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/873894/fulton-nil-a5-a1-agence-bernard-buhler Clipboard “COPY” Save this picture!© Sergio Grazia+ 36 Share Landscape Architect: “COPY” CopyAbout this officeAgence Bernard BühlerOfficeFollowProductsSteelConcrete#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousingParis-13E-ArrondissementFrancePublished on June 20, 2017Cite: “FULTON – A5 A1 / Agence Bernard Bühler” 20 Jun 2017. ArchDaily. Accessed 11 Jun 2021. ISSN 0719-8884Browse the CatalogAluminium CompositesTechnowoodHow to Design a Façade with AluProfile Vertical ProfilesRailing / BalustradesMitrexIntegrated Photovoltaic Railing – BIPV RailingMetal PanelsAurubisCopper Alloy: Nordic RoyalShelvingZeitraumWardrobe – Hide & ParkSignage / Display SystemsGoppionDisplay Case – Qd-ClassConcrete FloorsSikaIndustrial Floor CoatingsStonesCosentinoSurfaces – Silestone® Stone SeriesWindowsOTTOSTUMM | MOGSWindow Systems – FerroFinestra W20Panels / Prefabricated AssembliesULMA Architectural SolutionsMIS Facade PanelUrban ShadingPunto DesignPavilion – TentChairsInterstuhlConference Chair – Low With CastorsWoodreSAWN TIMBER co.Pre-Weathered Wood CladdingMore products »Save想阅读文章的中文版本吗?BlingBling,公寓的艺术形式化——巴黎富顿街区住宅一期 / Agence Bernard Bühler是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my streamlast_img read more

 

AI workshop & funding offer from Tech Trust & Microsoft

first_img Melanie May | 19 July 2018 | News About Melanie May Melanie May is a journalist and copywriter specialising in writing both for and about the charity and marketing services sectors since 2001. She can be reached via www.thepurplepim.com. Tagged with: artificial intelligence Technology  128 total views,  2 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis4  127 total views,  1 views today Advertisementcenter_img AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis4 Tech Trust and Microsoft have teamed up to offer charities help with using AI through a workshop and funding.To request a workshop, ideas must be submitted by this Friday 20 July.Applications are welcome from any UK charity that feels AI could benefit their good cause. The workshop will be personalised for each organisation, looking at pain points and strengths and investigating how they can more effectively meet their goals. They will be with one of Microsoft’s leading AI partners in the UK – at a time and place that suits the charity.Workshops will include:A strategic look at the charity’s mission, pain points and strengthsAn investigation of the quality of the charity’s data and discussion around how it be could be better used to fulfil its missionA discussion around how AI might help to solve the challenges above mentioned and how to make a business case for itAn exploration of the specific area that a proof-of-concept/value pilot might work for the charity’s AI projectApplicants will find out whether they have been successful by the end of July, and following the workshops, Microsoft will be offering a grant to a selected few charities so that they can continue developing the ideas that will then be more fully-formed.More information, along with the application form, is available on the Tech Trust site. AI workshop & funding offer from Tech Trust & Microsoftlast_img read more

 

French unions want retirement ‘reform’ scrapped

first_imgIt was a tough holiday for transportation strikers in France.  Their pay packet for December was basically empty.A dancing picket line, Paris, Dec. 24The struggle on the national railroad (SNCF) at 23 days is longer than a similar struggle over the SNCF retirement plan in 1995 and shows every sign of lasting longer than the 28-day struggle in 1986-87.Protesters are still in the streets. The two most militant unions representing SNCF workers called for a march on Dec. 28 near the Paris railroad station Gare du Nord, which was broken up by cops firing tear gas after some bank windows were broken.The public bank account set up by the General Confederation of Labor (CGT) for donations to support the strikers passed the million euro mark on Dec. 26. A big chunk of the money came from Twitch, a computer games network. At a rally in front of the headquarters of the Paris subway system, a high-ranking CGT leader, Marianne Ravaud, said, “This money came mostly in small donations from all over France.  It shows the basis of our support.” Public opinion polls report that between 60 and 70 percent of people in France support the strike.Most unions in France have no strike funds.One of the eight refineries in France has been shut down by its unions at the CGT’s call. Gas company Total’s refinery at Grandpuits, about 50 miles southeast of Paris, is still shipping out product in trucks but has lost its pipeline connection, so it will soon have to stop. Scattered outages of certain types of fuel have been reported, making drivers nervous. Picket lines have been set up at some bus depots from time to time, putting more pressure on the transportation system.In a blatant attempt to divide workers in order to win, the government of Prime Minister Édouard Philippe has not invited the head of the CGT, Philippe Martinez, to the next meeting of the striking unions and the government.  Meetings like this are generally where political strikes in France are settled.Ballet dancers at the Paris Opera held a picket line on Dec. 24 in front of the Opera House by dancing some scenes from Swan Lake accompanied by Opera musicians. The dancers’ retirement system dates back to 1698 under Louis XIV.  Dancers generally join the ballet corps between the ages of 8 to 10 and retire after 30 years of service, when they reach 42.FacebookTwitterWhatsAppEmailPrintMoreShare thisFacebookTwitterWhatsAppEmailPrintMoreShare thislast_img read more

 

Manhunt intensifies for killer of forensic psychiatrist, paralegals, as 4th victim is identified

first_imgChiccoDodiFC/iStock/Thinkstock(SCOTTSDALE, Ariz.) — As authorities in neighboring Arizona cities ramp up their investigations into the killings of a famed forensic psychiatrist and two paralegals, police have identified the victim of another fatal shooting — which may be connected the others.Marshall Levine was found shot to death just after midnight on Saturday, according to the Scottsdale Police Department.The 72-year-old man’s body was discovered by an acquaintance inside of his Scottsdale office in a neighborhood known as The Greens at Gainey Ranch — some 17 minutes away from where the paralegals were shot — and located on East Morgan Trail.The acquaintance called 911, but by the time emergency responders arrived, Levine was pronounced dead, police said.His ex-wife, Carol Kleinman, told ABC News that Levine was a psychiatrist, but only licensed to practice in New Jersey.Since moving to Arizona, Kleinman said Levine worked as a life coach and hypnotherapist and dealt with clients who often “are angry.”It’s unclear if Levine’s homicide is connected to the killings of famed Phoenix-based forensic psychiatrist Steven Pitt and the paralegals, Veleria Sharp, 48, and Laura Anderson, 49, the following evening.“We’re still trying to determine what involvement if any, it has,” Scottsdale Police Department’s Sgt. Ben Hoster told reporters on Saturday.Pitt, who earned acclaim as a forensic psychiatrist by consulting with law enforcement on a number of high-profile cases, most notably the mysterious death of JonBenet Ramsey back in 1996, was shot and killed at around 5:30 p.m. on May 31 as he was leaving his Phoenix office.He locked up his office and was “on his way out” when he engaged in an argument with another person by the elevator, Phoenix Police Department spokesman Sgt. Vince Lewis told ABC News.Lewis said a witness came forward who claimed to hear the verbal dispute before multiple shots were fired. No weapon was recovered from the scene, he added.Steven Pitt & Associates is headquartered in Phoenix, but Pitt worked on a number of nationally known cases, including Ramsey’s murder. The murder of the 6-year-old child beauty pageant competitor who was found dead in the basement of her family’s Boulder, Colorado home has never been solved.Pitt was brought on by Boulder police and the district attorney to consult on the case in February 1997.Meanwhile, the bodies of Sharp and Anderson bodies were both found by responding police officers about 2:15 p.m. Friday near the law offices where they worked, located on East 1st near North 75th Streets in the Old Town section of Scottsdale.One of the women was shot in the head and attempted to get help by flagging down a bus parked at a nearby intersection near the law firm, police said. That woman was rushed to a local hospital and pronounced dead, according to a police release.Responding officers followed a blood trail, which led them to her coworker. Police said in a statement she “was deceased from a gunshot wound.”On Saturday, investigators in Scottsdale say the killings of Sharp and Anderson were tied to Pitt’s murder.“We are confident that both crime scenes are related,” Lewis said.A sketch was released depicting the suspected shooter as a bald man wearing a dark hat with a short brim.A combined reward worth $21,000 been offered by multiple law enforcement agencies, including the Bureau of Alcohol, Tobacco, Firearms and Explosives and the Maricopa County Attorney’s Office leading to the capture and conviction of the shooter.So far, cops confirmed that they have fielded hundreds of tips. Copyright © 2018, ABC Radio. All rights reserved.last_img read more

 

Former Miss Kentucky admits she sent topless photos to young boy, officials say

first_imgKanawha County Sheriff’s Office(CROSS LANES, W.Va.) — She impressed beauty pageant judges with her fiddle playing and tugged at hearts with her personal battle with multiple sclerosis, but now former Miss Kentucky Ramsey Bearse is back in the spotlight for all the wrong reasons.The 28-year-old Bearse was arrested in West Virginia on suspicion of sending topless photos via Snapchat to a teenage boy, authorities said.“This is a very difficult day, and this is a shock to her, and to me, and to everyone else,” Bearse’s attorney, Al Emch, told reporters following her arraignment in Kanawha County, West Virginia, Magistrate Court.Bearse, an eighth-grade science teacher at Andrew Jackson Middle School in Cross Lanes, West Virginia, was charged with four felony counts of distribution or display of obscene matter to minors.She was arrested on Thursday after she admitted to investigators from the Kanawha County Sheriff’s Office that she sent the victim at least four topless images of herself between August and October, according to a criminal complaint. At the time, the victim was 14 or 15 years old, sheriff’s officials said.An investigation was launched on Dec. 5 when the victim’s mother contacted the sheriff’s office to complain that she discovered the nude photos of Bearse on her son’s cellphone, according to the criminal complaint.“The parent informed me that her son attended Andrew Jackson his sixth through eighth grade, during which Ramsey Bearse was a teacher during some of that time,” Detective S.D. Ferrell wrote in the criminal complaint.Officials at Andrew Jackson Middle School would only confirm that Bearse is a teacher at the school.“We cannot comment on personnel matters, but we will follow all applicable policies and procedures,” Kanawha County Schools officials said in a statement. “The safety and security of our students is our top priority.”Following her arraignment on Friday, Bearse, who has been married to a coal mining executive since 2016, told reporters, “I have no comment to make to you all at this time.”If convicted of the charges, Bearse faces up to 20 years in prison and a $100,000 fine.Emch’s request to have her released on her own recognizance was rejected by a magistrate, who told him during the arraignment, “I don’t think that would be proper at this stage.”Bearse was released from custody after posting a $10,000 property bond, officials said.She was crowned Miss Kentucky in June 2014 under her maiden name Ramsey Carpenter. She went on to compete in the 2015 Miss America pageant in Atlantic City, placing among the top 12 semi-finalists and winning the preliminary talent competition for her bluegrass fiddle playing.The winner of the Miss America pageant the year Bearse competed was Miss New York Nina Davuluri.During her reign as Miss Kentucky, Bearse promoted the platform of multiple sclerosis awareness, speaking out in numerous interviews about being diagnosed in 2010 with the disabling disease of the central nervous system. She served as spokeswoman for the National Multiple Sclerosis Society.Sgt. Brian Humphreys of the Kanawha County Sheriff’s Office said Bearse’s case is a wake-up call to all parents of young children.“There are a lot of bad situations that can arise because of a naive understanding of how social media works,” Humphreys told ABC affiliate station WCHS-TV in Charleston, West Virginia, adding, “So it’s important as a parent to monitor those things, keep tabs on who your children are communicating with.”Copyright © 2018, ABC Radio. All rights reserved.last_img read more

 

‘Open’ approach allows us to see the implications

first_img Organisations and employers can learn some early lessons from the way the CAC is handling the first of the union recognition applications. Although the statutory union recognition procedure came into force on 6 June 2000, only 16 applications for recognition have so far been submitted to the Central Arbitration Committee (CAC), which is handling these cases. This largely reflects the fact that most unions have been concentrating their efforts and relatively limited resources on seeking to achieve voluntary agreements. The CAC is operating in a fairly “open” manner with information about each application, including details of all written decisions of CAC panels, available at the organisation’s web site at www.cac.gov.uk This, together with the fact that three of this first group of applications have involved our members, has meant that the Engineering Employers’ Federation has been able to obtain an early indication of how the CAC is handling these applications. It has also enabled us to identify some practical implications for companies which become involved in this complex procedure.The first, and perhaps most important, implication is that once an application for recognition has been submitted to the CAC, things can move very quickly. In particular, relatively tight timetables are imposed within which the company has to respond to detailed questions from the CAC panel which has been appointed to handle the application and the CAC case manager. This can, therefore, place considerable burdens on the time of the company’s senior managers and their advisers if they are to defend their point of view properly. Second, the CAC would appear to be adopting a relatively informal and hands-on approach, including some – although, interestingly, not all – members of the CAC panel and the CAC case manager sometimes visiting the company involved to discuss the case. Also, and as the EEF had always anticipated, the CAC seems very keen to encourage the voluntary resolution of differences between the parties with the support of either the CAC panel itself or officials from Acas. Third, the role of the CAC case managers would appear to be very important. They are responsible for preparing papers for, and submitting information to, the CAC panel and are the principal point of contact with the company. It is therefore vital for companies and their advisers to maintain a close working relationship with the CAC case manager who is handling their application in order to understand the complex union recognition procedure, the function and role of the CAC and the way in which the CAC panel will be handling their case.Lastly, a recent decision in a case involving an EEF member has confirmed that a union’s application for recognition will not be accepted by the CAC if the company has already reached a recognition agreement with another union even if, as in this case, this agreement was signed only a few days before the union’s application was submitted to the CAC. By David Yeandle is director of employment policy at the Engineering Employers’ Federation Comments are closed. Related posts:No related photos. ‘Open’ approach allows us to see the implicationsOn 31 Oct 2000 in Personnel Today Previous Article Next Articlelast_img read more

 

Southern Utah beats Northern Arizona 85-80

first_img Tags: Big Sky/SUU Thunderbirds Basketball FacebookTwitterLinkedInEmailCEDAR CITY, Utah (AP) — Maizen Fausett and Dre Marin scored 21 points apiece as Southern Utah narrowly defeated Northern Arizona 85-80.John Knight III added 16 points for Southern Utah (16-3, 9-2 Big Sky Conference), which earned its sixth straight victory. Marquis Moore had 13 points. Fausett and Marin combined for 15 of the Thunderbirds’ 34 rebounds.Cameron Shelton had 25 points, nine assists and seven rebounds for the Lumberjacks (5-14, 4-9). Nik Mains added 18 points. Isaiah Lewis had 13 points and nine rebounds. Associated Press Written by February 24, 2021 /Sports News – Local Southern Utah beats Northern Arizona 85-80last_img read more

 

UK: BMT Fleet Technology Appoints New President

first_imgDarcy joins BMT from General Dynamics Canada where he held the post of Director of Business Development for Naval Programs and Project Management. There, he was responsible for the strategic planning, opportunity identification and pursuit for all naval programs and for the promotion of General Dynamics’ capabilities to the Canadian Department of National Defence.With over 30 years’ experience in the management of defence projects, Darcy’s previous assignments included requirements analysis, design development and review, cost control monitoring and contract compliance.With a dual Masters in Naval Architecture and Mechanical Engineering from MIT and a degree in Physics and Oceanography from Royal Roads Military College, he served in the Royal Canadian Navy as a Marine Systems Engineering Officer, a Ship Naval Architect and an Engineering Manager. Darcy is a member of the Project Management Institute, and a past President of the Ottawa Branch of the Canadian Institute of Marine Engineers.Commenting on his new appointment, Darcy Byrtus says: ““I am looking forward to working with the team at BMT Fleet Technology and its clients to continue delivering leading edge engineering, research and management services to the defence, oil and gas and shipbuilding industries.”David Bright, BMT’s Sector Director for Defence comments: “We are pleased to welcome Darcy to BMT, in an appointment that will continue to support our position in the global defence market. Darcy brings with him a wealth of knowledge in the project management of complex defence projects which will no doubt be invaluable to BMT’s future development plans.”[mappress]Press Release, March 20, 2014; Image: BMT View post tag: UK Industry news View post tag: New View post tag: Naval View post tag: BMT Back to overview,Home naval-today UK: BMT Fleet Technology Appoints New President View post tag: Navy View post tag: fleet View post tag: News by topic View post tag: President View post tag: appoints BMT FLEET TECHNOLOGYBMT Fleet Technology Ltd (BMT), a subsidiary of BMT Group Ltd, the leading international maritime design, engineering and risk management consultancy, has announced the appointment of Darcy Byrtus as President. Share this article March 20, 2014 UK: BMT Fleet Technology Appoints New President View post tag: Technologylast_img read more

 

Potential diabetes breakthrough

first_imgThe researchers who discovered betatrophin, HSCI co-director Doug Melton and postdoctoral fellow Peng Yi, caution that much work remains to be done before it could be used as a treatment in humans. But the results of their work, which was supported in large part by a federal research grant, already have attracted the attention of drug manufacturers. Researchers at the Harvard Stem Cell Institute (HSCI) have discovered a hormone that holds promise for a dramatically more effective treatment of type 2 diabetes, a metabolic illness afflicting an estimated 26 million Americans. The researchers believe that the hormone might also have a role in treating type 1, or juvenile, diabetes.The work was published today by the journal Cell as an early online release. It is scheduled for the May 9 print edition of the journal.The hormone, called betatrophin, causes mice to produce insulin-secreting pancreatic beta cells at up to 30 times the normal rate. The new beta cells only produce insulin when called for by the body, offering the potential for the natural regulation of insulin and a great reduction in the complications associated with diabetes, the leading medical cause of amputations and non-genetic loss of vision. <a href=”https://www.youtube.com/watch?v=Lk4DDlct__4″ rel=”nofollow” target=”_blank”> <img src=”https://img.youtube.com/vi/Lk4DDlct__4/0.jpg” alt=”0″ title=”How To Choose The Correct Channel Type For Your Video Content ” /> </a> Since the publication of this story, there have been questions raised about some of the conclusions reached by the researchers. The authors of the study wrote this clarification that was published as a Perspectives piece in the journal Cell. “If this could be used in people,” said Melton, Harvard’s Xander University Professor and co-chair of the University’s Department of Stem Cell and Regenerative Biology, “it could eventually mean that instead of taking insulin injections three times a day, you might take an injection of this hormone once a week or once a month, or in the best case maybe even once a year.”Type 2 diabetes, a disease associated with the national obesity epidemic, is usually caused by a combination of excess weight and lack of exercise. It causes patients to slowly lose beta cells and the ability to produce adequate insulin. One recent study has estimated that diabetes treatment and complications cost the United States $218 billion annually, or about 10 percent of the nation’s entire health bill.“Our idea here is relatively simple,” Melton said. “We would provide this hormone, the type 2 diabetic will make more of their own insulin-producing cells, and this will slow down, if not stop, the progression of their diabetes. I’ve never seen any treatment that causes such an enormous leap in beta cell replication.”Though Melton sees betatrophin primarily as a treatment for type 2 diabetes, he believes it might play a role in the treatment of type 1 diabetes as well, perhaps boosting the number of beta cells and slowing the progression of that autoimmune disease when it’s first diagnosed.“We’ve done the work in mice,” Melton said, “but of course we’re not interested in curing mice of diabetes, and we now know the gene is a human gene. We’ve cloned the human gene and, moreover, we know that the hormone exists in human plasma; betatrophin definitely exists in humans.”While Melton was clear about the need for more research before the hormone could be available as a drug, he also said that betatrophin could be in human clinical trials within three to five years, an extremely short time in the normal course of drug discovery and development.Working with Harvard’s Office of Technology Development, Melton and Yi already have a collaborative agreement with Evotec, a German biotech firm that now has 15 scientists working on betatrophin, and the compound has been licensed to Janssen Pharmaceuticals, a Johnson & Johnson company that now, too, has scientists working to move betatrophin toward the clinic.But were it not for the federal funding of basic science research, there would be no betatrophin. A Melton proposal titled “Searching for Genes and Compounds That Cause Beta Cell Replication” impressed National Institutes of Health grant reviewers, and received federal funding for 80 percent of the work leading to the discovery of betatrophin.“At a time of great uncertainty for federal research funding, the discovery of betatrophin is a reminder of the importance of basic research,” said Harvard Provost Alan Garber. “Were it not for a National Institutes for Health grant, this promising new approach to treating diabetes might never have come to light.”As is often the case in basic science research, serendipity played a role in the discovery of betatrophin, which Melton and Yi originally called Rabbit because they discovered it during the Chinese Year of the Rabbit, and because it makes beta cells multiply so quickly.For more than 15 years the major focus of Melton’s work has been not type 2 diabetes but the less common type 1, or juvenile diabetes, which he began focusing on when his son was diagnosed with it as an infant. (The disease later was also diagnosed in his daughter.) Additionally, most of Melton’s work has involved using stem cells, the fundamental building blocks of all human organs, as disease treatments and targets for drug discoveries. But stem cells played no direct role in the discovery of betatrophin. It was, rather, a classic example of scientists with sufficient resources asking questions, and pursuing answers, that fell outside the usual scope of their laboratories and institutes.“I would like to tell you this discovery came from deep thinking and we knew we would find this, but it was more a bit of luck,” explained Melton, who in addition to his roles at Harvard is a Howard Hughes Medical Institute investigator. “We were just wondering what happens when an animal doesn’t have enough insulin. We were lucky to find this new gene that had largely gone unnoticed before.“Another hint came from studying something that people know about but don’t think much about, which is: What happens during pregnancy?” he said, “When a woman gets pregnant, her carbohydrate load, her call for insulin, can increase an enormous amount because of the weight and nutrition needs of the fetus. During pregnancy, there are more beta cells needed, and it turns out that this hormone goes up during pregnancy. We looked in pregnant mice and found that when the animal becomes pregnant this hormone is turned on to make more beta cells.”Melton and Yi have been working on the project for more than four years. But the big breakthrough came on Feb. 10, 2011. “I was just sitting there at the microscope looking at all these replicating beta cells,” said Yi, and he could barely believe his eyes. He said he never had “seen this kind of dramatic replication.”At first unsure whether to repeat the experiment or to tell Melton right away, Peng said he rushed into Melton’s office, printed out the image he was seeing, and showed it to Melton, telling him they probably had a breakthrough. “I showed him this picture and told him this is a secreted protein, and he was really, really excited about this result.”“I remember this very well,” Melton recalled. “It’s a black-and-white picture where you’re looking at a section, like a section through a sausage, of the whole pancreas.  When you normally look at a black-and-white picture of that, it’s very hard to tell where the beta cells are, the insulin cells.“But in this test,” he continued, “any cell that was dividing would shine up bright and white, like a sparkle. He showed me this picture where the whole pancreas is largely black, but then there were these clusters, like stars of these white dots, which turned out to be all over the islets, the place where the beta cell sits. I still keep that black-and-white picture. We have much fancier color ones, but I like the black-and-white picture, because it’s one of those moments when you know something interesting has happened.  This is not by accident. I’ve never seen any treatment that causes such an enormous leap … in beta cell replication.”The following morning, when Yi sat down at his lab bench, there was a formal-looking, cream-colored envelope lying on the brown surface of the bench. He opened it up, and took from the envelope a handwritten note from Melton. It read:“Dear Peng, I can hardly sleep — I am so excited by your result. It’s a tribute to your hard work and hard thinking. Can’t wait to see the data from the repeat. Doug.”last_img read more