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Postexposure Marburg vaccination protects monkeys

first_img The authors conclude, “These results evidently have important clinical implications, and offer a new treatment approach for [Marburg] haemorrhagic fever and perhaps for other viral haemorrhagic fevers.” The Marburg vaccine is based on a modified version of the vesicular stomatitis virus (VSV), which causes mouth inflammation in livestock. Researchers made the vaccine by inserting a surface glycoprotein gene from the Marburg virus into a live but weakened recombinant form of VSV (rVSV). In a previous study, the vaccine protected four monkeys when they were exposed to the virus 4 weeks after vaccination. May 2, 2006 (CIDRAP News) – An experimental vaccine protected monkeys from the deadly Marburg hemorrhagic fever virus even though they weren’t vaccinated until after exposure, according to a report published in the April 29 issue of The Lancet. The finding suggests that the vaccine could be effective for postexposure protection of laboratory or healthcare workers accidentally exposed to the Marburg virus, says the report by a team of US and Canadian researchers. In assessing immune responses after 10 days, the researchers found low to moderate amounts of immunoglobulin M (IgM) against Marburg in four of the five treated monkeys and moderate amounts of IgG in all five. However, no cellular immune response was detected. The authors write that the Marburg virus dose they used represents a worst case for a needlestick accident. Because many human exposures probably involve much smaller amounts of virus, the “window” for postexposure immunization is probably longer than 20 to 30 minutes, they suggest. Future animal studies, the report says, should focus on how long after exposure the vaccine can be used successfully and whether the vaccine used in this study, based on the Musoke strain of Marburg, will work against other strains. There is no licensed vaccine and no specific treatment for Marburg fever, which resembles Ebola hemorrhagic fever and is fatal in most cases. A Marburg epidemic in Angola in 2004 and 2005 killed 227 of 252 people infected, according to Angolan government figures. The vaccine’s protective mechanism in rhesus macaques remains to be determined, the article says. However, the same is true of postexposure protection conferred by rabies and smallpox vaccines in humans. See also: Although three of the five immunized monkeys had a fever by the sixth day after exposure, all five of them survived, the report says. In contrast, the three control monkeys all died by the 12th day, after showing signs of Marburg fever. The controls all had high levels of Marburg virus in their blood by day 6. Polymerase chain reaction testing showed transient viremia in four of the five treated monkeys on day 3, but plaque assays revealed no Marburg virus in their plasma at any point. Jun 7, 2005, CIDRAP News story “Ebola, Marburg vaccines work in monkeys” Daddario-DiCaprio KM, Geisbert TW, Stroher U, et al. Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessement. Lancet 2006 Apr 29;367:1399-404 [Abstract] In the new study, eight rhesus macaques were injected with 1,000 plaque-forming units (pfu) of Marburg virus. About 20 to 30 minutes later, five of the monkeys were injected with the experimental vaccine, and the other three were injected with nonspecific rVSV formulations for control purposes. The time interval was assumed to be about how long it would take to vaccinate someone after an accidental needlestick exposure. The experiment was conducted in a biosafety level 4 lab at the US Army Medical Research Institute of Infectious Diseases (USAMRIID) in Maryland. The research team included Kathleen M. Duddario-DiCaprio of USAMRIID as first author, along with other scientists from USAMRIID, the Uniformed Services Universtiy of the Health Sciences in Bethesda, Md.; Canada’s National Microbiology Laboratory in Winnipeg, Man.; the University of Manitoba, Winnipeg; and the National Institute of Allergy and Infectious Diseases in Bethesda, Md. May 25, 2004, CIDRAP News story “Russian scientist dies of Ebola after lab accident”last_img read more


Russia 2018: Nigeria to play Algeria, Cameroun, Zambia

first_imgNigeria will play Zambia’s Chipolopolo, Cameroun’s Indomitable Lions and Algeria’s Fennecs in the final round of qualification series for the 2018 FIFA World Cup finals.The draw conducted at the Cairo Marriott Hotel put all former African champions in the same Group B, with reigning continental champions Cote d’Ivoire to tackle Gabon, Mali and Morocco in Group C.Tunisia’s Carthage Eagles head Group A that also includes Libya, Democratic Republic of Congo and Guinea, and Ghana’s Black Stars will do battle with the Pharaohs of Egypt, Congo’s Red Devils and Uganda’s Cranes in Group E. Senegal’s Teranga Lions, which reached the World Cup quarter –finals in its debut in 2002, head Group D that also includes South Africa’s Bafana Bafana, Burkina Faso’s Etalons and Cape Verde’s Blue Sharks.“It is a tough draw, but then I have always said that you have to beat the best to get to the World Cup. Now we have the draw, we know how to prepare. The preparation has to start right now and we must make good use of every single day leading to the kick –off of the series.“The other pools are tough as well, because for me, you can never afford to under –rate any team these days. Now we must quickly sort out the issue of Head Coach and his assistants and put every other thing in place in good time,” NFF president Amaju Pinnick said.Algeria knocked Nigeria out of the race to the 1982 FIFA World Cup, but Nigeria also overpowered Algeria to qualify for the 1994 finals in USA.Nigeria beat Algeria 3-0 to lift her first –ever Africa Cup of Nations title, on home soil in 1980, but the Fennecs avenged by beating the Eagles 1-0 to also nick their first African title, on home soil, ten years later.Cameroun stopped Nigeria from reaching the 1990 FIFA World Cup finals, winning 1-0 in Yaounde in a group contest even though Nigeria won the home leg 2-0 in Ibadan. In Yaounde, only weeks after the death of Samuel Okwaraji, Nigeria needed a draw to shove aside the Lions but lost 1-0.In a friendly in Belgium in October last year, the Super Eagles steamrolled the Lions 3-0.GROUP A: Tunisia, Libya, DR Congo, GuineaGROUP B: Zambia, Cameroun, Algeria, NigeriaGROUP C: Gabon, Mali, Cote d’Ivoire, MoroccoGROUP D: Senegal, South Africa, Burkina Faso, Cape VerdeGROUP E: Ghana, Egypt, Congo, UgandaShare this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegramlast_img read more


Revealed: Rabiu out of Egypt clash

first_imgGhana could miss hardworking midfielder Rabiu Mohammed for next month’s crucial World Cup playoff against Egypt after suffering an injury that could rule him out of action for six weeks.The 23-year-old, who plays for Russian side Kuban Krasnodar, suffered the injury on Thursday night during their Europa League tie against Swiss club St Gallen.Mohammed was substituted in the 20th minute of the match but the nature of the injury is unknown.However, Kuban coach Dorinel Munteanu says Rabiu, woh joined the club about three weeks ago, is expected to be out of action for about five to weeks.This means Rabiu will be unavailable for Ghana when they host Egypt on 13 October in Kumasi which is just about four weeks away.“The injury of Rabiu is unpleasant for us. Maybe he will be out of action for 5-6 weeks,” Kuban coach Dorinel Munteanu said. We just got this player. We were very much looking forward to his contribution to the team so we have to look for another option.”Rabiu is a key player for Ghana and his absence could create a vacuum in the Ghana team’s midfield.last_img read more