Category: dsbpepoq


Postexposure Marburg vaccination protects monkeys

first_img The authors conclude, “These results evidently have important clinical implications, and offer a new treatment approach for [Marburg] haemorrhagic fever and perhaps for other viral haemorrhagic fevers.” The Marburg vaccine is based on a modified version of the vesicular stomatitis virus (VSV), which causes mouth inflammation in livestock. Researchers made the vaccine by inserting a surface glycoprotein gene from the Marburg virus into a live but weakened recombinant form of VSV (rVSV). In a previous study, the vaccine protected four monkeys when they were exposed to the virus 4 weeks after vaccination. May 2, 2006 (CIDRAP News) – An experimental vaccine protected monkeys from the deadly Marburg hemorrhagic fever virus even though they weren’t vaccinated until after exposure, according to a report published in the April 29 issue of The Lancet. The finding suggests that the vaccine could be effective for postexposure protection of laboratory or healthcare workers accidentally exposed to the Marburg virus, says the report by a team of US and Canadian researchers. In assessing immune responses after 10 days, the researchers found low to moderate amounts of immunoglobulin M (IgM) against Marburg in four of the five treated monkeys and moderate amounts of IgG in all five. However, no cellular immune response was detected. The authors write that the Marburg virus dose they used represents a worst case for a needlestick accident. Because many human exposures probably involve much smaller amounts of virus, the “window” for postexposure immunization is probably longer than 20 to 30 minutes, they suggest. Future animal studies, the report says, should focus on how long after exposure the vaccine can be used successfully and whether the vaccine used in this study, based on the Musoke strain of Marburg, will work against other strains. There is no licensed vaccine and no specific treatment for Marburg fever, which resembles Ebola hemorrhagic fever and is fatal in most cases. A Marburg epidemic in Angola in 2004 and 2005 killed 227 of 252 people infected, according to Angolan government figures. The vaccine’s protective mechanism in rhesus macaques remains to be determined, the article says. However, the same is true of postexposure protection conferred by rabies and smallpox vaccines in humans. See also: Although three of the five immunized monkeys had a fever by the sixth day after exposure, all five of them survived, the report says. In contrast, the three control monkeys all died by the 12th day, after showing signs of Marburg fever. The controls all had high levels of Marburg virus in their blood by day 6. Polymerase chain reaction testing showed transient viremia in four of the five treated monkeys on day 3, but plaque assays revealed no Marburg virus in their plasma at any point. Jun 7, 2005, CIDRAP News story “Ebola, Marburg vaccines work in monkeys” Daddario-DiCaprio KM, Geisbert TW, Stroher U, et al. Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessement. Lancet 2006 Apr 29;367:1399-404 [Abstract] In the new study, eight rhesus macaques were injected with 1,000 plaque-forming units (pfu) of Marburg virus. About 20 to 30 minutes later, five of the monkeys were injected with the experimental vaccine, and the other three were injected with nonspecific rVSV formulations for control purposes. The time interval was assumed to be about how long it would take to vaccinate someone after an accidental needlestick exposure. The experiment was conducted in a biosafety level 4 lab at the US Army Medical Research Institute of Infectious Diseases (USAMRIID) in Maryland. The research team included Kathleen M. Duddario-DiCaprio of USAMRIID as first author, along with other scientists from USAMRIID, the Uniformed Services Universtiy of the Health Sciences in Bethesda, Md.; Canada’s National Microbiology Laboratory in Winnipeg, Man.; the University of Manitoba, Winnipeg; and the National Institute of Allergy and Infectious Diseases in Bethesda, Md. May 25, 2004, CIDRAP News story “Russian scientist dies of Ebola after lab accident”last_img read more


Germany ramps up coronavirus tests to 500,000 a week

first_imgGermany has boosted its coronavirus test rate to 500,000 a week, a virologist said Thursday, adding that early detection has been key in keeping the country’s death rate relatively low.”The reason why Germany has so few deaths compared to the number of infected people can be explained by the fact that we carry out an extremely large number of laboratory diagnostic tests,” said Christian Drosten, who heads the Institute of Virology at Berlin’s Charite University Hospital.”Estimates from the last days show that we are carrying out half a million tests a week,” he added. Topics : Drosten also highlighted Germany’s dense network of laboratories spread across its territory as a factor contributing to early detection.Meanwhile the research ministry said it would commit 150 million euros (US$164 million) to improve communication between hospitals and laboratories about coronavirus patients’ health data, hoping the information exchange could feed into development of a vaccine.Official data compiled by the disease control agency Robert Koch Institute show that 36,508 people have been infected in Germany, including 198 who have died from the disease.At 0.54 percent, Germany’s death rate is far lower than the 7.3 percent in Spain where 4,089 deaths were recorded for 56,188 confirmed cases. center_img France has also recorded 1,331 fatalities of 25,233 confirmed infections — a death rate of 5.2 percent.Besides the large-scale testing, experts in Germany also said that the virus has largely affected a younger, healthier section of the population compared to elsewhere.At the same time, experts have repeatedly warned that in the country where almost a quarter of the population is over 60, the number of deaths could still skyrocket if people do not stick to measures to help halt contagion. Lockdown measures are in place across Germany, preventing people from leaving their homes except for essential trips, while most shops, restaurants and bars are closed. last_img read more


Rights group welcomes draft rules that could end China dog meat trade

first_imgDraft rules by Chinese authorities that specify dogs as “companion animals” rather than livestock were hailed by a rights group Thursday as an “encouraging” step towards ending the dog meat trade in the country.China’s Ministry of Agriculture and Rural Affairs published a list of animals that can be traded for meat Wednesday that included pigs, cows, chickens and sheep, but excluded dogs and cats.The new list also specified that livestock refers to animals that have been domesticated and bred by people for a long time in order to provide products such as meat, eggs and fur. Humane Society International said in a statement Thursday that the latest draft document “could signal a critically important shift in China’s desire to see an end to the dog and cat meat trade”.”Coming so soon after Shenzhen’s dog and cat meat ban, it is incredibly encouraging,” said its international media director Wendy Higgins.”This is the first time the national government in China has explicitly explained why dogs… are excluded from the official livestock list, stating that these are companion animals and not for eating,” she added.The animal protection group estimates some 10 million dogs a year are killed for China’s dog meat trade.According to activists, thousands are killed for a festival in the town of Yulin in southern Guangxi province every year, and eaten to mark the late-June summer solstice. China in recent weeks banned the sale of wild animals for food, citing the risk of diseases spreading from animals to humans. The illegal animal trade has been blamed for the emergence of the new coronavirus outbreak that has spread across the globe and killed more than 87,000 people.While trade and consumption made a comeback despite similar measures taken after the 2003 SARS outbreak, there are signs that such moves are being taken more seriously this time.The southern city of Shenzhen passed a law last week banning the consumption of wild animals, including dog and cat meat, a step also welcomed by animal rights activists.center_img Topics :last_img read more


Spain’s economy recovering as jobs numbers grow, minister says

first_imgSpain’s economy has started to recover after the severe impact of the coronavirus pandemic, Economy Minister Nadia Calvino said on Wednesday, citing favorable employment indicators following the gradual easing of a lockdown since May.She said 1 million furloughed workers were working again and 300,000 new workers had registered with social security.”The recovery phase has already started,” she told parliament, adding that the trend change was backed by various indicators, mainly the latest job creation data. Topics : While the Spanish economy is heading for the worst contraction on record in 2020, of up to 11.6%, the Bank of Spain forecast the recovery would start in the second half of this year, with GDP likely to bounce back and grow by 7.7% to 9.1% next year.It expected the economy to bottom out in the second quarter with a slump of around 22%, but recovery in the tourist-dependent country should be a little stronger than the euro zone average.Early indicators, such as Spanish services and factory PMIs, showed businesses partly resumed activity in May after plunging in April.Spain is emerging from a three-month lockdown after the virus caused one of the world’s heaviest death tolls.last_img read more


Joseph Mariathasan: Shareholders or stakeholders?

first_imgConflicts between shareholder value maximisation and stakeholder satisfaction could be resolved if all external impacts of a corporation were fully pricedIn the case of accountability, The Economist makes the fair point that it is not clear how CEOs should know what “society” wants from their companies. The domination of the economy by large firms means that a small number of unrepresentative business leaders “will end up with immense power to set goals for society that range far beyond the immediate interests of their company”. The power of social media companies like Facebook is a clear illustration that this is already occurring, even in the absence of collective capitalism.Collective capitalism leans away from change, The Economist argues: “In a dynamic system firms have to forsake at least some stakeholders: a number need to shrink in order to reallocate capital and workers from obsolete industries to new ones. If, say, climate change is to be tackled, oil firms will face huge job cuts.”However, influential economist Milton Friedman argued that companies should not “make expenditures on reducing pollution beyond the amount that is in the best interests of the corporation or that is required by law in order to contribute to the social objective of improving the environment”.What that has meant is that companies are free to cause a negative impact to other stakeholders in the pursuit of maximising shareholder value as long as they stay within the law as it stands. Corporations are able to operate without the impact of their activities fully priced into their profit and loss statements because they are not legally forced to do so. It justifies private gains at the expense of public losses.The conflict between shareholder value maximisation and stakeholder satisfaction could be resolved if all external impacts of a corporation were able to be fully priced and accounted for.In the US, an initiative was set up in 2011 called the Sustainability Accounting Standards Board Foundation with the objective of establishing industry-specific disclosure standards across ESG topics.Though it is still essentially an independent entity with no legal powers, it is modelled on the Financial Accounting Standards Board and the International Accounting Standards Board. A key element of its activities is dialogue with the US regulator regarding accounting disclosures.Accounting for all externalities would be only a first, albeit essential, step.Knowing that burning a rainforest to create cattle grazing land may produce far more in terms of public losses than the private gains to the cattle rancher (and taxes accrued to the government) is one thing. It may prevent ESG-focused investors from investing, which may only benefit other investors with less scruples.What would resolve the issues raised by The Economist – and promote sustainable investment with a shareholder maximisation philosophy – would be if corporations were charged for all external negative impacts created by their activities.However, it may never happen – not be because it is such a revolutionary concept, but because many of today’s corporations would be producing large overall losses rather than net profits. The battle lines are being drawn up in the debate over whether shareholder value maximisation or satisfying all stakeholders should be the primary objective of corporate management.It is a critical issue for investors focused on environmental, social and governance (ESG) issues – but the arguments can often be off the point. The Economist magazine sees itself as a standard bearer for “the classical liberalism of the 19th century”. This means it is a great supporter of the traditional idea of free markets with the view that “government should only remove power and wealth from individuals when it has an excellent reason to do so”.Its leader on 22 August – in response to the revised statement of corporate purpose issued by the US Business Roundtable – was excoriating: “However well-meaning, this new form of collective capitalism will end up doing more harm than good. It risks entrenching a class of unaccountable CEOs who lack legitimacy. And it is a threat to long-term prosperity, which is the basic condition for capitalism to succeed.” These arguments are worth considering by all ESG-focused investors. The Economist argues that the sort of “collective capitalism” espoused by the US Business Roundtable suffers from two pitfalls: a lack of accountability and a lack of dynamism.last_img read more


EIA: Puerto Rico LNG imports bounce back to peak levels

first_imgIn 2018, Puerto Rico’s liquefied natural gas (LNG) imports neared 2016 annual levels, according to the recently released LNG Annual Report by the U.S. Department of Energy’s Office of Fossil Energy. Imports into Puerto Rico were disrupted in 2017 after Hurricane Maria made landfall as a Category 4 hurricane on September 20, 2017.Puerto Rico imported 60.3 billion cubic feet (Bcf) of LNG in 2018, a level similar to the total LNG imports of 61.3 Bcf in 2016, EIA said on Monday.Puerto Rico relies on fuel imports to meet most of its power generation needs. Nearly half of its power generation was fueled by petroleum products and one-third of its power generation was fueled by natural gas in 2017.All of Puerto Rico’s LNG imports are used for electricity generation, EIA said.From 2013 through 2016, Puerto Rico received an average of two LNG cargos per month, with each cargo providing about 2.5 Bcf of natural gas, or 159 million cubic feet per day (MMcf/d).Image courtesy of EIAThe Peñuelas LNG terminal in Ponce, on the southwestern coast, is the territory’s sole LNG terminal and began operating in 2005. Peñuelas typically operated at almost 90 percent of its regasification capacity of 186 MMcf/d before the expansion.After Hurricane Maria made landfall in late September 2017, Puerto Rico’s LNG imports declined as less natural gas was needed during widespread electricity outages. In the last three months of the year, Puerto Rico only received one LNG cargo per month, averaging 78 MMcf/d and bringing the 2017 total average to 46.4 Bcf, or 24 percent lower than the previous year’s average.Puerto Rico resumed its two-cargoes-per-month level of LNG imports four months after the hurricane, although restoration efforts on electricity infrastructure took much longer. By April 2018, the Puerto Rico Electric Power Authority (PREPA) had restored electric power to 95 percent of its customers.In August 2017—the month before Hurricane Maria—the Federal Energy Regulatory Commission (FERC) had approved a 60 percent expansion of the Peñuelas regasification capacity, from 186 MMcf/d to 279 MMcf/d.According to FERC filings, EcóElectrica, the parent company, stated that disruption to the PREPA electric system and delays in restoration efforts had delayed the project from entering service until May 2018. Since the expansion, Puerto Rico’s imports increased and reached a monthly record volume of 275 MMcf/d in September 2018.Puerto Rico is looking to further expand its natural gas consumption to displace fuel oil for electricity generation. However, the territory is currently limited in its ability to receive cargos from the Lower 48 states because of Jones Act restrictions. In December 2018, Puerto Rico requested a 10-year waiver to the Jones Act, which requires goods or passengers moved in U.S. coastal waters between U.S. ports to be carried on vessels that are U.S. constructed, owned, crewed, and flagged.The 10-year waiver would allow Puerto Rico to move LNG from the Lower 48 states with prices benchmarked to the Henry Hub, or at prices that are lower than importing natural gas from foreign countries. Since September 2016, Puerto Rico has imported 100 percent of its LNG from Trinidad through long-term contracts.last_img read more


Tietz tops Bruns Cup opener at Jackson

first_imgJACKSON, Minn. (May 30) – Ken Tietz started his trek toward a third career Dominick Bruns Memo­rial Challenge Cup Chase crown with the Saturday checkers at Jackson Speedway.The IMCA Sunoco Stock Car victory was Tietz’ first this season and was good for $1,000. Devin Smith, Shaun Bruns, David Wickman and Jason Mickelson completed the top five.“I was very thankful to get this one,” said Tietz, who topped Challenge Cup Chase point standings in 2011 and 2013. “There were some very good drivers up here.”Tietz had started third in the field of 26, then fell back to fifth behind Wickman, Smith, defending Chase champion Jim Larson and Dustin Larson.After using multiple lines to work his way to the front midway through the 20-lapper, he moved up on the track and stayed in front to the finish.Smith earned runner-up honors after starting ninth.Challenge Cup Chase events paying $1,000 to win are July 17 at Murray County Speedway and July 26 at Redwood Speedway. The champion earns a $1,000 share of the $2,000 point fund.IMCA driver Shaun Bruns and his wife Becky founded the Dominick Bruns Memorial Foundation in 2008 after losing their son to Sudden Infant Death Syndrome. The series point fund is gener­ated by the sale of T-shirts and racing shirts by the foundation along with contributions from area sponsors.Feature results – 1. Ken Tietz; 2. Devin Smith; 3. Shaun Bruns; 4. David Wickman; 5. Jason Mickel­son; 6. Luke Sathoff; 7. David Reisdorfer; 8. Jake Bruns; 9. Adam Klocke; 10. Dan Veenstra; 11. Jesse Olson; 12. Gary Mattison; 13. Shane Bruns; 14. Terry Klocke; 15. Andy Alten­burg; 16. Levi Feltman; 17. James Richert; 18. Derek Voehl; 19. Kevin DeBaere; 20. Josh Telecky; 21. Roger VerDoorn; 22. Devin Kuehne; 23. Jim Larson; 24. Dustin Larson; 25. Derek Green; 26. Michael Bruns.last_img read more


Man U reach Europa League quarter-finals

first_imgRelatedPosts Ighalo: My best moment as ‘Red Devil’ EPL: Crystal Palace stun sloppy Man U EPL: Red Devils attack Palace Anthony Martial struck a late winner as Manchester United secured a 2-1 win over LASK Linz to advance to the Europa League quarter-finals.Ole Gunnar Solskjaer made nine changes to his side from the team that started the final game of the Premier League season, with only Harry Maguire and Brandon Williams retaining their places. But perhaps the lack of motivation affected Solskjaer’s men as they begun slowly at an empty Old Trafford.Indeed, it was nearly a moment to remember for the Austrian visitors when centre-back Andres Andrade headed against the crossbar inside the first 10 minutes.United struggled to piece together their usual passing moves and LASK were happy to capitalise, with Marko Raguz heading just over from an inviting cross by the lively Rene Renner.United finished the half without a shot on target and that only capped a drab first-half display.But things picked up after the interval, with Odion Ighalo and James both going close. Whatever was said in the dressing room seemed to have an effect as United began to create all of the chances.But LASK finally made the breakthrough with a stunning 30-yard strike from Philipp Wiesinger whistling into the top corner past the helpless Sergio Romero.If there were any concerns as to whether there would be a shock comeback, Jesse Lingard put them to bed just two minutes later, tucking underneath Alexander Schlager to make it two goals in as many games.Solskjaer sent on Paul Pogba and Tahith Chong late on to inject some life into his side, while 18-year-old Teden Mengi made his debut.Another substitute, Martial, found the winning goal two minutes from time after a crafted pass from Juan Mata to seal a 7-1 aggregate win, but doubts remain over the quality of United’s fringe players after a sub-par display. Tags: ANthony MartialLASK LinzManchester UnitedOdion IghaloOle Gunnar Solksjaerlast_img read more


Siskova Dismisses Nigeria’s Quadre at Lagos Open

first_imgRiya Bhatia from India won against Claudia Coppola from Italy in 6-2, 7-6(4) result and Zeo Kruger from South Africa won against Kajsa Rinaldo Persson from Sweden in 6-4, 6-4 ending.Jasmin Jebawy from German was coasting home before injury knocked out Rosalie Van Der Hoek from Holland the result was at 6-4, 1-0 before he retired due to thigh injury. Mihaela Djakovic from Serbia won against Merel Hoedt from Holland in 4-6, 6-2 and 6-4 result. Action resumes this morning with all the courts busy for other first round matches.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Barakat Oyinlomo Quadre The hope of Nigeria’s Barakat Oyinlomo Quadre of making an impact in the second leg at the ongoing Lagos Open Tennis 2018 came to an end last night after a resounding defeat from Anna Siskova from Czech Republic in one of the first round matches.Playing on court three at the Lagos Lawn Tennis Court, Onikan, the Nigerian only managed to improve her game in the second match but the more experienced Czech lady had a better game strategy to win the two sets at 6-0, 6-3 before a fairly large crowd that watched the proceedings.In some other matches, Clothilde De Bernardi was better against his fellow brother from France Estelle Cascino with 6-0, 6-2 final result. While Dutch lad, Noa Liauw Fong got the better side of Alexandra Riley from USA in 6-0, 6-2 scoreline.last_img read more


Porous Syracuse defense fails to limit Cincinnati’s overpowering rushing attack

first_img Facebook Twitter Google+ CINCINNATI — As tailback George Winn churned out yard after yard, and as three different quarterbacks tormented 11 different defenders, just how far the Syracuse defense has slipped suddenly became clear. The unit that stifled Jawan Jamison, that left Ray Graham limping, that yielded negative rushing yards to Connecticut has lost its way.For the second straight game against the exact same scheme — the zone read — Syracuse’s once-stout defense wilted.“They didn’t need a quarterback, man,” defensive tackle Jay Bromley said. “They ran the ball on us. And that’s just something we have to take to heart. Two weeks in a row we gave up a lot of rushing yards, and we can’t do that if we want to win.”Last Saturday it was 369 rushing yards allowed in a narrow, come-from-behind win against South Florida. This Saturday it was 263 yards in a game where the offense couldn’t bail out the defense when its tackling was poor and its front seven was porous. And as the Bearcats (6-2, 2-1 Big East) abandoned the pass with a lead in the fourth quarter, the Orange (4-5, 3-2 Big East) still had no answer. Cincinnati kept possession for 11:02 of the final 15 minutes and secured a 35-24 win.During the week, linebackers coach Steve Morrison said playing consecutive games against running quarterbacks was beneficial to the SU defense. It meant two straight weeks of practice against the zone read — a play where the quarterback has the option to hand the ball off or keep it himself and run — and plenty of time to tweak the game plan after the first round against South Florida.AdvertisementThis is placeholder textBut Saturday’s performance indicated more confusion than confidence. Less improvement and more regression.After Jeremiah Kobena fumbled the opening kickoff to give Cincinnati the ball deep in Syracuse territory, Winn took handoffs on three of the next four plays and ran right through the middle of the Orange defense on all of them, eventually reaching the end zone for a touchdown.“Two weeks in a row people are hitting those same gaps on us,” head coach Doug Marrone said.It was the beginning of a 165-yard, three-touchdown day for Winn, who carried the ball on more than one-third of Cincinnati’s total offensive plays. His physical running style overpowered the Orange defenders from start to finish, and most of his runs featured at least one — if not two or three — broken tackles.Winn seemed to grow stronger as the game wore on, bludgeoning the Syracuse defense over and over again. He accounted for all 47 yards on the last scoring drive of the game that began in the third quarter and ended with a touchdown early in the fourth, ripping off back-to-back 18-yard runs in the process. The first showcased his power, as he bowled over Shamarko Thomas — arguably the Orange’s most physical player — after bursting through the initial hole. And the second was a portrayal of speed, bouncing an inside handoff to the outside and down the sideline.Winn finished the drive himself with a 2-yard touchdown.“(The tackling) was a little bit better than last week, but not how we normally play,” linebacker Marquis Spruill said.Timely and effective quarterback keepers from the zone-read play supplemented Winn’s workhouse effort. Three different quarterbacks (Munchie Legaux, Jordan Luallen and Brendon Kay) broke off runs of at least 12 yards, with Legaux and Luallen rushing for 71 yards between them.The Bearcats attempted only 11 passes in the second half, relying on their dominant rushing attack to drain the clock and break the Orange’s will. In fact, the trio did so little throwing on Saturday that the longest pass of the game was completed by Winn on a halfback jump pass — a la Tim Tebow — that caught the Orange completely by surprise and allowed tight end Travis Kelce to walk in for a 37-yard touchdown.“That’s a hell of a trick play,” Bromley said.And though Syracuse kept the elusive Ralph David Abernathy IV in check for most of the game, the one long run he did manage was significant. He scampered 15 yards down the right sideline as Jeremi Wilkes and Markus Pierce-Brewster both whiffed on attempted tackles, picking up a first down on a drive that ate up enough clock to prevent the Orange from building on its three-point lead before halftime.“Those guys have averaged over six yards per carry for a reason,” Marrone said.Part of the reason is their talent, which has guided Cincinnati to six wins in its first eight games. But the other part is their opponents, and the Orange provided little resistance on Saturday.For the second straight game, its defense was gashed and exploited for more yards than any point during the 2011 season. The result is a pattern that other teams can notice and exploit, which only spells trouble for a team on the verge of another bowl-less season.“We can’t just let teams run the ball on us,” Bromley said. “Because that means the next team that watches that film is just going to be chomping at the bit to come against us.” Comments Published on November 4, 2012 at 12:11 am Contact Michael: | @Michael_Cohen13last_img read more